OK. Now how about database access (with support for prepared statements), regular expressions, and networking?
At least you were kind enough to let us know.
Arc is already capable of supporting some subset of applications that are serious in your sense. News.YC is at least moderately serious in that sense.
Actually I think I have seen a library for MzScheme that does it this way.
Sure, it's somewhat more verbose for this toy examples - but every intermediate expression (and the whole thing) is a Lisp-Object in its own right.
You would not even need macros.
Edit: There is a place for macros here to make things less verbose. Just write a macro that 'compiles': (* (+ a (* b))) into the form above.
For convenience you can offer a function that builds RegExps out of strings in the usual way.