In my experience, every limit is immediately relaxed when requested; number of VPCs (I see people do horrible things to work around this all the time! Just ask!), EC2s / region, SES limits (need to send 10 million emails / day? No problem!), API Gateways / account, total ASGs... I believe all of these are there to keep you from shooting yourself in the foot through automation gone wrong or inexperience.
I've seen some crazy complicated architectures, where just sending an email or lifting up the phone solves the thing within an hour.