It is satirical. If you go to the main page, at http://www.larry.denenberg.com/ , you'll see this is described as "a celebration of Don Knuth". The jokes require you to understand who Donald Knuth is and what he's done. A premise is that we're in the far future (20002), and some of the details are fuzzy.

It starts with the title. "Knuth 3:16" makes it sound like Knuth wrote one of the books of the bible. Among CS researches, Knuth's works are held in high esteem.

The "3:16" part more specifically refers to Knuth's study of chapter 3 verse 16 of every book of the Bible. See http://www-cs-faculty.stanford.edu/~uno/316.html .

The analysis is of the 16'th sentence of the 3rd chapter of some of Knuth's (presumed) most famous works, plus commentary.

"He was an enthusiastic musician" likely refers to the organ in his house http://www-cs-faculty.stanford.edu/~uno/organ.html .

The text "he started life as a college football coach" refers to Knute Rockne, who is shown in the picture. This is a joke on the similarity of Knuth and Knute, with the premise that in 20002 these two famous people have been blurred into one.

"Big Dummies Guide to Visual Basic" refers to a Dr. Fun (2000) cartoon at http://www.ibiblio.org/Dave/Dr-Fun/df200002/df20000210.jpg as if it were real.

Probably Donald Knuth's book "3:16 Bible Texts Illuminated" where Knuth goes through chapter 3, verse 16, of most books in the Bible.

http://www-cs-faculty.stanford.edu/~uno/316.html

http://www.amazon.com/3-16-Bible-Texts-Illuminated/dp/089579...

While we’re at it, Knuth has also released a book (which is just transcripts of 5-6 lectures) wherein he discusses the 3:16 project: "Things a Computer Scientist Rarely Talks About"

http://www-cs-faculty.stanford.edu/~uno/things.html

http://www.amazon.com/Things-Computer-Scientist-Language-Inf...

I can't possibly be satire, it must be "historical records"[0]

[0] http://www.imdb.com/title/tt0177789/