People who actively try to subvert the efforts of science through shit studies, or lobby government officials to skew their judgement in ways that are objectively wrong (public health, environmental health, etc.), or undercut local business by taking advantage of defenseless populations overseas, or take more than they give solely because they can cut a piece of profit out, betraying the trust of the person that hired them or the trust of their clients, and 'who cares if the company goes under, not my problem, on to the next gig', are assholes. By only some definitions are those people winners.
I'd say, given a population of 7+ billion, most assholes simply make a bed of shit and then lie in it, dragging their family and friends down with them. Nothing winning about it.