we looked at jspm and switched to webpack. detailed comparison here:
http://blog.dripstat.com/why-we-switched-from-jspm-to-webpac...
And, excuse me for saying that, but I found your post lacking in substance. Writing "It's super slow, we've tried everything" doesn't show us about what you've tried and with a detailed explanation maybe the thousands of eyeballs who saw that post would be able to help you find the problem you had. ;)
https://www.reddit.com/r/javascript/comments/42ozl3/why_we_s...
we are serving our JS files as static assets behind nginx - we dont run nodejs on the server. does webpack allow you to create static assets (htmls,css,js) and serve them ?
the big issue is of course the fact that some libraries (Handsontable) are coming from github and are not on npm. is it possible to use them - with overrides,etc. ?