For building stateful UI's Clojurescript + Reagent beats anything else out there.
For data science and algorithms Clojure beats anything else I've used.
For backend web development Rails is still miles ahead of any Clojure workflow.
Datomic is interesting but there's still too much incidental complexity to be super productive with it. It's hard to build a startup on Datomic because of the pricing and productivity hit, but could see it being useful in the enterprise where speed is less important.
I'm very interested in mobile development with Clojurescript on top of React Native, but haven't found a tutorial that wasn't written in hieroglyphics, so assuming that needs some more time to mature.