I'm not sure the Witness can live up to Braid, but we'll see.
The famous quote in the epilogue makes you think of an important historical event, but plausibly that's metaphorical and the game is about something more personal, existential. Maybe the game isn't about anything but making you reflect. Maybe it's an expression of particular events in Blow's life. Maybe all of the above.
He also said he responded to people who emailed him their interpretation. At the time of the interview only one person correctly guessed Blow's own interpretation.
I can't even imagine what the real answer could be.
I remember when I was originally playing the game right after it came out, and I was stumped by a puzzle and then found the "official" walkthrough and it inspired me to try my best at the game to get through it. And it really made the game way more rewarding, enjoyable, and memorable.
(The game that did that to me most often was Catherine. At least five or six times. And given that I never got very good at the puzzle version (in the arcade game in the bar), probably still at least a couple more still lurking in there if I picked it up again.)
I tried my best to enjoy it (Fez too) but I can't seem to get past the fact that they are platformers, which I have discovered I just flat-out do not like.