The iPad Pro with Apple Pencil is almost $1000 LESS than a comparable Wacom Cintiq 2. And the Apple Pencil is a game changer compared to the older Wacom tech.
It's the most natural "feeling" stylus out there. Apps that support the tilt feature of the pencil make drawing and painting incredibly fun. And the increased scan rate of the iPad Pro screen (240 times per second) make the pencil super accurate (compared to using third-party pencils on older iPads).
And while the iPad Pro doesn't run full OSX, the Adobe Apps designed for iOS and Apple Pencil feel refreshing, like new again. They're simplistic by design, and hopefully Adobe will keep improving them (Creative Suite on the desktop has stagnated for 10 years).
Microsoft OneNote is free as well. I'm getting the full Surface Pro experience as well, and feel kind of guilty for doing it for some reason :-)
Point being, there's no shortage of apps these days.
Finally, AstroPad (another third-party app) lets you use the "full versions" of any app you've got on your OS X desktop, on the iPad. You can screen share and control OS X with touchscreen and Apple Pencil support. So painting in Photoshop on the iPad Pro is possible too.
I purchased the iPad Air a couple years ago and promptly returned it. Maybe the app support wasn't there, or the cheap feeling third-party keyboard case turned me off.
The iPad Pro with the Apple Pencil is a keeper.