Lately I've been using Python/PyQt with Nuitka, which transpiles the Python to C++ and then compiles it into a standalone exe + dlls. It (more or less) just works too, very cool indeed!
For example, if I had anything that used numpy (which is most of my code) or Qt, or a lib that uses opengl, it would either fail outright saying "can't find blarg" or it would spin forever. Now I understand that the process of transpiling something huge like numpy and then compiling it will be fairly demanding, but I've literally left this stuff running in a tmux session for a day or two and it showed now sign of ever finishing.
I'm not asking you to debug my stuff or anything, but have you had a different experience? Is there a trick to getting Nuitka to build code that leverages the python ecosystem? I would really like to figure this out, because the alternatives are really quite terrible, IMO. If Nuitka can be made to work with build times less that a week, I think he's really on to something.