This line of thinking is one of many general problems with the world. Many of us walk around fighting a battle in our head that does not exist. The last line stands out the most because it presumes there could be a winner. How can that be if you're the one who's making the rules?
It gets worse for founders because there's always something to be doing and always some problem going on. A couple of mental hops and they've now incorrectly associated their peace with the success of their business. This is bound to fail even if you do very well -- you'll always be fighting "problems".
Forgiveness goes a long way. Learning how to forgive others will teach you how to better forgive yourself and visa-versa. It's not noble to lash yourself on the back with a mental whip because you didn't live up to some superficial aim.
I don't care what happens to this stupid body of mine -- I'll die someday like the rest of you. This awareness shields me from damaging myself with superficial qualities that change with each passing whim.
Finally, I don't suggest pumping your body full of drugs to protect yourself from your thoughts. First, work with the thoughts and forgiveness then move onto drugs if they would help you better find the peace you need to forgive and let go.