After moving to Azure Websites for hosting, I started developing my web app in Win10 and so far it has worked great for me. My app stack is -

* ReactJS * Flask * SQLAlchemy * SQL Azure

My dev tools are -

* Atom for JS dev * PyCharm for server side code * SQL Express for dev db

All the CLI tools for both React and Flask (and Python in general) work pretty well in Win10 PowerShell.

Note, my main dev environment is Ubuntu with scipy/scikit-learn in Python but I have always been pretty comfortable with Windows and PowerShell.