There's nothing here that seems superfluous when creating a web application. If you want to take advantage of advances to the Javascript language, you're going to have to go either with Babel/Traceur or some other kind of ES6 transpiler, or Typescript, which while ostensibly is it's own language, seems more and more headed to becoming defacto ES7.
If you work with a team of developers and want a modular structure for developing components as opposed to 10,000 line js files, you're going to need some kind of module system / bundler. This is hardly new, it's baked into .Net web projects (forget the name), and stuff like require.js has been around for ages. Webpack is just the latest iteration of that concept.
If you're building an app of any complexity, you're probably going to want to do some unit testing. For that, you'll need a test runner. Karma's a decent choice.