It does not use the movie file at all, so yes.

What it does is this. It goes and fetch all available subtitles for a movie (You can limit this if you provide a partial release name). It then selects a candidate dialog from all the subtitle files based some criteria and prints out the time at which that dialog appear in the each of the subtitle file.

You can use this to co-relate the best subtitle file for your movie file.

A downside of this approach is that you have to seek forward and actually find out when the dialog actually occurs in your movie file.