I currently work on estimating emphysema extent in CT lung scans. Emphysema can be very diffuse and it is not possible to label individual pixels, so instead we try to learn the local emphysema pattern from a global label. Neural networks are interesting for this problem because the learn the features, but it is also a "problem" because the features might not make physically sense, which could make it hard to transfer the model and convince clinicians that they should use it.