The ability to look back into the past and get full-resolution metrics is a huge deal. With Ganglia or Graphite (which aggressively downsample old data) there's a lot of squinting to try to make out patterns past a week or so.
That said, we also use HBase as our main data store, so we have a lot of experience with operating it. I'm not sure I could recommend OpenTSDB to an organization that lacks that expertise.