There's a lot of stuff that Mozilla does, but I wish there were a way to donate and say "try your best to allocate my money for project X" within Mozilla (Corporation, which I now understand is not the one supported by donations). While Mozilla Corporation seems to primarily focus on Firefox and Firefox OS, I would like to see more attention and effort devoted on the following:
1. Mozilla Thunderbird to get a lot more attention and a strong roadmap (something like the now defunct Mozilla Messaging initiative).
2. A good high end Firefox OS phone that is widely available and gives a good enough competition to Android and iOS, even though it's quite late and it may not have an apps collection like the other platforms do.
3. Reviving Persona/BrowserID, which many people here and elsewhere have asked for. From recent discussions I do understand this is not easy to do, but we need someone knowledgeable and available to take the lead and have Mozilla's brand pushing this for a wider reach.