He is probably busier than the average FB employee.
It becomes a badge of honor to let unused vacation expire at the end of the year because you just didn't have time to take it.
I've seen it more than once.
What this really means is, no acquisitions for Facebook once leave starts (except maybe the ones he's already greenlit). At the CEO level, you focus on direction, strategy, and top-level execution of said direction and strategy. You're not designing and doing grunt work. If anyone can step back from a large corporation and watch things keep on humming along, it's the CEO.