The really challenging thing with antibiotics (as a reply below notes) is that if you create a great new antibiotic, nobody will use it unless they have to.
There is resistance out there, but for most infections, the 40+ year old antibiotics work just fine. It's not like almost every other disease where the best drug gets used first line.
Unless the financial incentives are fixed, it's unlikely there will be enough incentive to do the R&D to create new antibiotics.