You mean a return to the wold before antiobiotics? The world that existed when my grandparents were born? I doubt the few generations of people born during the "antibiotic era" have any meaningful genetic traits connected with the use of antibiotics
https://publichealthmatters.blog.gov.uk/2015/11/02/i-need-an...
> If we can’t stop the infection, however, we can’t stop the sepsis. A world without effective antibiotics will mean that every one of the 100,000 people who develop sepsis each year in the UK - every one of the 18 million people with sepsis each year worldwide - could certainly die from simple infections like chest and water infections. A human could die from infection every second.
> When I started treating people with bacterial infections it was rare that I didn’t have tablet antibiotics that I could treat them with; rare that I needed to keep people in hospital to treat their infections. Now every week, I treat young women with last resort antibiotics for urinary tract infections. Rather than given them a simple 7-day tablet course, they have to stay in hospital for a week or more, or come to the hospital every day for an injection.
https://publichealthmatters.blog.gov.uk/2014/11/18/10-reason...
> When we discuss antibiotic resistance we talk about a frightening future and rightly ask for action to stop the problem from getting worse. But this doesn't mean it's all just an issue for future generations. It’s estimated that 25,000 people already die every year in Europe because of infections resistant to antibiotics and in the USA the figure is 23,000 people, every year.
https://publichealthmatters.blog.gov.uk/2015/11/18/7-more-re...
> In 2013 there were 480,000 recorded cases of multi drug-resistant TB (TB that can’t be treated by our usual medicines). TB is a bacterial infection that can spread through the lymph nodes and blood stream to any organ in your body. It commonly affects the lungs and while a lot of people might not consider it to be an issue in the UK, or think it couldn’t affect them, this isn’t true. 37 million lives worldwide have been saved by antibiotic treatment for TB since 2000. In some countries, it is becoming increasingly difficult to treat MDR-TB. Treatment options are limited, recommended medicines are not always available, and patients experience many adverse effects from the drugs.
Such a case has never happened in the past, unless I didn't learn about an antibiotics crisis in ancient Egypt.
We used antibiotic technology to "evolve" resistance to bacteria. Bacteria responded much more rapdily than we could have naturally and is now a different organism than what our grandparents had to contend with. Now our technological "evolution" is unable to keep up with natures and we face a new threat not an old one. One we helped to create.