For example, it's a goal to have WebAssembly modules interopt with the ES6 module system, and as soon as GC is supported, you'll be able to access the DOM and the JavaScript context in WebAssembly [0]. Both of these are huge steps towards ensuring that wasm plays well with everything that's great about the web today.
[0]: https://github.com/WebAssembly/design/blob/master/Web.md
(Disclaimer: I'm a Google Chrome PM contributing to the WebAssembly project)