What is needed:
1 - Legalization and regulation like that of regular prescription and over-the-counter drugs to:
1a - Make sure drugs are pure, labeled property and are not mixed with undesired compounds.
1b - Stop imprisoning and killing people over what they choose to do to their own minds and bodies.
1c - Stop the violence and corruption caused by the illegal drug trade.
2 - Much better education about how to use drugs safely and constructively.
3 - An end to the stigmatization of drug users.
4 - A sincere and well thought-through tackling of the issues (like poverty and mental health issues) that lead to self-destructive abuses of drugs and other substances.