>There have been some investigation of settings and high vs. low generally doesn't give you an advantage or disadvantage either way.
Yes and no. In a game like Starcraft where cloaked units give a slight glimmer when moving, pros universally optimize settings to enhance this glimmer as much as possible, and low graphics is one of the settings they use. More so though pros just stick to what their used to regardless of objective performance. It's why so many CS pros still use 4:3 aspect ratio.