Editing of Pig DNA May Lead to More Organs for People
nytimes.com
nytimes.com
So the genes were put in some cells that then created the enzymes that actually had the CRISPR/cas9 mechanisms? If so, that's clever. I had imagined that the CRISPR was delivered more directly and I was wondering how you could ensure delivery of CRISPR to all cells in the tissue. With a gene that actually produces an enzyme that delivers CRISPR, the treatment would continue in the cells until the gene was disabled.
What would really be interesting is to have the CRISPR edit include the gene that created the enzyme so that it could recursively deliver the treatment. Of course I wouldn't think that we'd want a recursive treatment like that in an eventual solution... but it would be interesting.
All this tinkering begs the question: Which is easier, tinker pig DNA to make pigs compatible with humans, or tinker human DNA to make humans with pig-like-brains that grow fast enough to be used as organ source? Does it ethically make any difference?
What if we could grow human bodies with no consciousness what so ever (this might not be even super hard, or require DNA tinkering, just damage the fetus where appropriate brain parts are about to develop), wouldn't that be the most humane option? Since we wouldn't be killing anything, but hunk of human meat that never had a conscious thought...
And modifying pig DNA to make them compatible with humans is indeed proving to be very doable.
Source: my mother works in this field. http://medschool.umaryland.edu/facultyresearchprofile/viewpr....
I think you wait until people survive early trials to call it real.
Last year I wrote a paper on Oryx and Crake and found a case of using slightly modified pig membranes/ligaments to repair human ones...We're just getting closer to OrganInc.
I'm not sure if maybe Atwood already knew this to be the case, but it seems like quite the coincidence.
https://en.wikipedia.org/wiki/Races_in_Revelation_Space#Pigs
(not really horror)
:)
http://www.technologyreview.com/news/540076/surgeons-smash-r... http://medschool.umaryland.edu/facultyresearchprofile/viewpr...
https://www.kidney.org/news/newsroom/factsheets/Organ-Donati...
The other goals you mention don't strike me as the sort of thing which merely need more resources to be solved.