At Uber, we started with Apache Thrift, but found many things about it limited and broken with dubious code quality for some languages. Furthermore we had more ambitious ideas like application layer sharding (uber/ringpop) and service discovery and routing (uber/hyperbahn).
We're still using the thrift protocols (uber/thriftrw) with our rpc library (uber/tchannel), but could have built on top of another IDL format like protobufs (v3).
For those curious about the RPC interface, just check out: https://tchannel.readthedocs.org/en/latest/
The interface supports all sorts of things
This is all over TCP right now and designed for performance and service to service communication, but there is nothing preventing the addition of HTTP (via XHR or WebSockets) as a transport for allowing web apps to speak with tchannel services. I contributed to the Apache Thrift implementation that allows this (https://github.com/apache/thrift/blob/master/lib/nodejs/lib/...). The implementation for tchannel would be similar, but rely on XHR/WS in the browser and the `http` module instead of the `net` module in NodeJS on the server. It's trivial to write a proxy frontend that relays TJSONProtocol on the frontend to a Thrift binary protocol like TBinaryProtocol or TCompactProtocol.
https://github.com/uber/hyperbahn https://github.com/uber/tchannel https://github.com/uber/ringpop-node https://github.com/uber/ringpop-go https://github.com/uber/idl https://github.com/uber/tcurl https://github.com/uber/tcap
etc.