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You could write a foreign data wrapper for TokuDB. For some examples: https://wiki.postgresql.org/wiki/Foreign_data_wrappers

You can also mix-and-match. You could use PostgreSQL's regular storage engine for some tables, and TokuDB for some others.

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TokuDB is built for a single-process model with threads for connections. This is incompatible with PostgreSQL's multi-process model, and patching TokuDB to support such a model would be a large effort. Not impossible, but a lot of work.

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