A person would take the software, and import a tab-delimited list of words + definitions. Some of the definitions would have web links. They'd then have a the software + list, which is the thing they'd distribute to end users. The software should have some way of searching the lists.
Many of the end users are not going to be sophisticated computer users, so asking them to import a word list is probably not practical.
Changes to the wordlist would be handled by updates.
You would either sell this to NHS health trusts and let them deal with updating it, or you'd sell it as a service and brand it and deal with the updates for them. Or you could include ads, but you'd need to carefully screen out any ads for alcohol or other problematic public health stuff.
Example entry:
PLACE [tab] Patient Led Assessment of the Care Environment http://www.england.nhs.uk/ourwork/qual-clin-lead/place/
(I don't trust Logmein and want to move away from Lastpass and haven't found a satisfactory alternative).