On the one hand, you have a mediagenic, celebrity CEO with little relevant qualifications or experience (and a penchant for posing for photographs in Steve Jobs-style turtlenecks) who raised millions at a stratospheric valuation on the promise of revolutionising healthcare and disrupting the lab testing industry, while making lofty claims about "scientific advancement", but has ultimately failed to deliver on that promise, while appearing to erect a facade designed to conceal the fact that the service they're offering isn't all that different from the incumbents', and deflecting questions about the technology they (claim to) have developed. The suggestion that they broke federal rules by fudging proficiency-testing is the icing on the cake.
On the other hand, the suggestion that they broke the rules is merely an allegation. On the topic of the company's progress towards it's stated goals, science is hard and a ten-plus-year time horizon doesn't appear unreasonable for achieving the objective Theranos is aiming for. Plus, they have successfully rolled out the HSV1 test. It's seems reasonable to expect that more will follow.
I am instinctively skeptical of founders who seem to focus more on cultivating their media profile than on getting their heads down and actually delivering. There are people whose overriding motivation is maximising media exposure but who completely lack the ability to deliver what they promise. Sometimes their behaviour is down to naiveté, over-confidence, self-delusion or a deep-rooted desire for celebrity, fame or recognition (such people seem to wear the CEO "brand" in the same way that others wear Dolce & Gabbana or Prada). Othertimes, they're simply con-artists, looking to fleece gullible customers or investors.
Given that Theranos has gained FDA approval for the HSV1 test, and the suggestion that they broke federal rules is unproven, I think Holmes deserves the benefit of the doubt. Her principal crime appears to be that she was a bit naive in making overly optimistic promises and embracing the celebrity CEO role, which has made her a target for schadenfreude.