Another place that's got a high quality of life for low cost of living is St. Augustine, Florida. It's an architecturally significant city with several colleges, great art scene, wide beaches.
You don't need to look any further than the warnings in the post you're replying to for a response. If you're dating, prefer lots of social interaction, or attend a lot of big-city events, then you're going to have a bad time living in southern Missouri.
San Francisco is not a good place for straight women to date. No one talks about it, because it's not politically correct, but in my observations they come here, and are lonely.
There's just too many single women, and not enough men. I have a very attractive ex-girlfriend, and we had so many conversations about social life, or lack there of. It got to the point, where I took her out and watched what took place. Guys--way below her league wouldn't talk to her unless she aggressively talked to them first.
I know I get hammered because I'm not being politically correct, and yes--there's always the exceptions, but at least in San Francisco it's difficult for sigle women looking for a steady relationship.
I'll point out the politically incorrect thoughts, and save you time:
I shouldn't have stereotyped. I shouldn't have assumed some females are looking for a steady relationship. I shouldn't have mentioned looks/personality when I said "way below her league". I probally left out something that hurt someone deeply--sorry.
Some of us choose to remain close to specialized healthcare, that we trust.