I can speak from Cuba, since I am originally from there. Cuba has been closed for 50 years to America, but that is changing now. There are really smart people, that just don't have the necessary access to capital or good advice.
Creating a branch of YC there would have a tremendous impact for local economy and people in addition of being a great business venture in a market that has been closed for half a century and is finally open. It's also worth mentioning that given the current economic situation, funding a startup in Cuba would only take a small fraction of what it takes to fund it in the US, with a lot of potential ROI since almost every industry can be disrupted significantly.