FWIW, two (partially self-serving) suggestions:
1. Try set up a lab in Cambridge at some point down the road.
2. Pay particular attention to CS theory: it's (arguably) high-impact and very cost effective --you can practically fund an entire generation of researchers in a subfield for a fraction of the cost of, say, a major interdisciplinary initiative. See for instance what the Simons foundation is doing at Berkeley[1].
Best of luck with what you're doing. You can end up actually changing the world in this way.