I think it depends on your use case. If your page views are mostly new users (e.g. you're a content publisher), then cachability doesn't matter too much. But if you're writing a web app hoping to have high engagement with users that return to the site frequently, it's likely you can be pretty effective with caching.
Also - I kinda doubt that browser caches use a simple LRU replacement policy. I suspect they have some heuristics built in to guess what is most likely to be re-used. I don't know for sure though...it would be interesting to know.
Even jQuery from the Google CDN is rarely present in a cache. They are great for navigating around the same site in one session, but not effective for much more than that.
It's currently using 350MB.