The core of the modern web isn't static: it's transactional, it's personalized, and it's end-to-end encrypted for both security and privacy. How does a distributed caching model accommodate such things? If it can't, how can it be a replacement for http? If it's not a replacement for http, is it at least better than current CDNs? If so, how?

It's hard to imagine you haven't already thought of these questions and answered them somewhere, but this non-article certainly doesn't address it or point to better resources (besides "buy my book!").