I have been thinking about this as well. One idea I've been wondering about:

* Will more remote vacation destinations, including owning a second home in these areas, be more in demand? Buying or renting a vacation house that's a 5-6 hour drive away may not be as ideal if you have to drive yourself there. If you own or can rent a self driving car though, the trip may not seem quite as far. Longer road trips may become more popular, and geographical far places may feel closer than they used to. Demand in coastal or mountainous locations currently far removed from cities may increase.