"Prescription drug abuse and addiction kill far more people in the U.S. every year than all illegal drugs combined."
https://www.psychologytoday.com/blog/wicked-deeds/201404/pre...
https://www.psychologytoday.com/blog/wicked-deeds/201404/pre...
Also, these data include things like acetaminophen overdoses (estimates run from 100 to 1000 deaths per year).