Granted, the high-level interface you want to present to the programmer is something like RPC. The two application-level communication paradigms in Urbit are a transactional "poke" and publish-subscribe.
A key difference is that a successful poke (a) contains no return data and (b) is piggybacked on the packet ack. Actually the whole transaction is piggybacked on the packet ack ("single acknowledgment" or "E2E acknowledgment.") Oh yeah, that's another feature that crosses OS/protocol lines.
This lets us produce a particularly non-leaky network abstraction against not procedure/function calls, but Arvo's stacked event calls (if normal events are a lot like GOTOs, Arvo events are more like GOSUBs). So it's not quite RPC. But it's fair to be reminded of RPC.
But at the actual packet layer, a network is a bus for sharing large (but not too large) unsigned integers, which may or may not arrive anywhere. (Network programming is quite a bit easier, by the way, given a bus-width-independent language that can just model packets and blobs as big atoms, then operate on them functionally.)
Effectively, a packet you hear is something that someone said, not something that someone told you to do. Hearing it is learning something. Idempotence at the packet level is crucial, because if someone tells you something twice, it's the same as telling you once. The protocol exists to answer the question: what happens to me if I learn this number?
It's only a short step from here to defining the entire state of an endpoint as a permanently fixed function of the list of numbers you've learned. The computer's state is a function of its packet log. What could be more natural? Why would anyone define a computer in any other way?
But of course, defining a computer as a pure function of its packet history requires you to define its VM and OS as part of defining the protocol.
And a general rule of protocol design is that your chance of achieving a compatible protocol is inversely proportional to the square of the length of the specification. It's also inversely proportional to the extensibility of the protocol.
So you're going to squeeze all of Unix into your RFC? Or even all of JS, bless its soul? And again, you wind up looking for something like Urbit. You may just be interested in the cow head, but you can't get to it without building the whole cow.