If you mean shortcuts like argument-splats and implicit return-statements,
https://github.com/anko/eslisp-fancy-function is on npm.
All you need is to npm install it and do
(macro function (require "eslisp-fancy-function"))
If you want it in all files, it's safe to cat that onto the start of each as a build step.
I do see your point though—it's a very common thing for people to want to use. I'm adhering strictly to UNIX design priciples for now because I'm afraid of featuritis, but perhaps that will change as the project matures.
I'm playing with the idea of having a separate convenience "getting started" package called "eslisp-coffee" or something, which acts like the core eslisp compiler but with a certain set of macros attached by default. What do you think?