Not all publishers subscribe to the low quality Google AdExchange. In fact, they typically have a variety of ad bids, and the highest bidding ads are chosen for placement programmatically.
Edit: I just visited vogue.com. Guess who served me my ad? doubleclick. It was relevant and I bet it was programmatic. Programmatic does not mean random. Ad placement programs have a lot more data to work with than any individual at the publisher. There's a lot more sense to it than manual prediction