I love the theme of how discovery and research are the source of both melancholy and ecstasy. Gopnik herself seems to have found fulfillment and an escape from other troubles in the exciting new questions she encountered about Hume's influences. The other side of the same coin is Hume's depression during the period when he found himself incapable of making significant progress on his thesis.
> "When you’re young, you want things: work, love, children. When you reach middle age, you want to want things. When you’re depressed, you no longer want anything. Desire, hope, the future itself—all seem to vanish, as they had for me. But now I at least wanted to know whether Hume could have heard about Desideri. It was a sign that my future might return."
The other theme of interest to the tech community is the interplay of personal and professional lives. If you consider the two aspects of one's life, personal relationships and professional fulfillment, each provides a hedge against possible problems with the other. Interesting explorations in one's work can help pull one from other problems in life.
There is a significant time-varying component of probabilistic luck in whether one's life and work will be fulfilling, but I think it makes sense to constantly strive to bias these probabilities towards outcomes that involve working on exciting projects and building meaningful personal relationships.
I think this article is a strong descriptive companion to Zach Weinersmith's popular comic about 'eleven lifetimes' http://www.smbc-comics.com/?id=2722