An ASIC is always going to be at least 10x better than a CPU/GPU for performing the same algorithm. The question isn't whether or not an ASIC can beat NVIDIA, the question is whether the target market is large enough to support an ASIC company.
At Isocline we assume that this market IS big enough to support an ASIC. Our competition is not NVIDIA, it's the future all-digital ASIC company that can do the same thing, but without all of the whiz-bang technology. If we have to, we could probably fall-back to be that all-digital company, but I'd prefer to maintain our technology advantage.
NVIDIA's advantage is flexibility, there's always going to be a lot of demand for that.