NTFS because you have to, ZFS has a little restriction on it that makes it difficult to be 'of choice' and EXT4 needs to go away for huge volumes.
Linux with a huge volume? Use XFS.
Linux with a huge volume? Use XFS.
Kit was a HP DL380p, SmartArray 420i SAS array, CentOS 7 about 3 months ago.
Outage caused by a large UPS explosion that took out 100 machines. No NTFS or ext3/4 trouble at all.