I had a go at using UCT to explore a search space earlier this year (not games, but selecting a good sequence of decisions inside a simulation).
The problem I ran into with this approach was that the algorithm has no way to generalise or lift experience from one explored state to other similar / unexplored states, and my search space was large. So having to evaluate each state at least once was prohibitive.
This isn't really a criticism of how well UCT can tackle the problem as framed, but more a criticism of how much better one might be able to do with a bit more structure -- e.g. perhaps with the addition of some kind of similarity metric between states, along with some bounds or assumptions on how the values of "similar" states should relate to each other.
It seems like combining some machine learning / statistical / approximation techniques to approximate the true state->value function with a UCT-like approach to guide exploration could be very effective for the right problem, but getting it to work well might be more of an art than a science.
If anyone has any pointers to reading about this kind of thing, I'd be most grateful! I have previously read about "approximate dynamic programming" techniques, e.g. [1]
[1] http://castlelab.princeton.edu/Papers/Powell-NRLWhat%20you%2...