https://c2.staticflickr.com/8/7244/7300035260_8e872e201c_b.j...
Probably somewhere close on the list is the MAGNET STOP button on a MRI machine, it destroys the superconducting magnet and vents the incredibly expensive helium into the atmosphere.
http://a406.idata.over-blog.com/0/01/25/36/magnetic-field-st...
No cover, no toggle, no delay, you want them big and red and able to be pressed by someone with two broken wrists.
And while liquid helium isn't cheap, filling the dewar once isn't that expensive compared to the MRI itself. You have to contiuously refill liquid helium, which is a significant running cost.
https://en.wikipedia.org/wiki/Scram#/media/File:NS_Savannah_...
It got pushed once in 1955 by a supervisor who had to jump over the table to hit it, because the employee in charge of the panel was chatting on the phone with his wife.
It was hit too late though, and half the core melted down.
(That's particularly bad for breeder reactors, because it can cause a nuclear explosion.)
Ironically, the entire chain-of-events was precipitated by a different wrong button being pressed.
He said it wasn't particularly fair as the company he worked for wasn't responsible for the system having the problem, they just did the display part and made the mistake of displaying their company name rather conspicuously. Try explaining that to an angry man standing on top of a nuclear reactor...