I use it with Feedly with around 600+ feeds. I also have a Google CSE set up with my subscriptions. Google Reader had the best search ever. Sad that it was shuttered.

The majority of content comes from few big sites so I put them into HF and just scan them and mark as read while others are organised as folders like:

  Interesting	|
  Interesting	| Australians
  Interesting	| Prose

  My state	| General
  My state	| Films
  My state	| Religion

  Religion	| General
  Religion	| Catholic
  Religion	| Orthodox

  Tech		| Personal Computing
  Tech		| Vendors

  Tools		| Excel
  Tools		| Emacs
  Tools		| Vim
  Tools		| PIM

  Career	| General
  Career	| SAP
  Career	| Professional accounting

  Books		| General
  Books		| Public domain
  Books		| University Press

  Language	| Blogs
  Language	| English
  Language	| Advice

  Country	| Defence
  Country	| Nutjobs
  Country	| Foreign media

RSS is really great and I wouldn't replace it with anything else from the restricted web.