Google also turned off flash (except the "main content") by default in Chrome 45. It's now click to play.
Do you find anything missing in particular, or non-functioning?
Not the OP, but I found that Google Play Music wouldn't work with Flash disabled in Safari, but also wouldn't tell me why. I had to manually enable it, then it worked fine.
You shouldn't miss many things. Maybe some embedded videos on news sites that are not youtube, but I can live with that.
I'm running Firefox without flash for months already, everything is fine ;)