Apple has absolutely control on anything and everything that would run on this thing, I don't think it is about paying licenses to Arm. When you have almost infinite money, in long term having a leaner/ faster / more efficient custom ISA is better and lucrative than depending ARM or Intel for innovation. They can make it run existing applications with a transformation layer (already done by Nvidia/Transmeta mentioned elsewhere in this thread) So, I don't see why not.