This is a topic very dear to me, and I'd like to share the brief conclusion to Walter Pater's The Renaissance. The full text is available online[0]; it's very much worth the read if you're interested in literary appropriations to the problem of human connection and the nature of experience.

Experience, already reduced to a group of impressions, is ringed round for each one of us by that thick wall of personality through which no real voice has ever pierced on its way to us, or from us to that which we can only conjecture to be without. Every one of those impressions is the impression of the individual in his isolation, each mind keeping as a solitary prisoner its own dream of a world. Analysis goes a step farther still, and assures us that those impressions of the individual mind to which, for each one of us, experience dwindles down, are in perpetual flight; that each of them is limited by time, and that as time is infinitely divisible, each of them is infinitely divisible also; all that is actual in it being a single moment, gone while we try to apprehend it, of which it may ever be more truly said that it has ceased to be than that it is.

To such a tremulous wisp constantly re-forming itself on the stream, to a single sharp impression, with a sense in it, a relic more or less fleeting, of such moments gone by, what is real in our life fines itself down. It is with this movement, with the passage and dissolution of impressions, images, sensations, that analysis leaves off–that continual vanishing away, that strange, perpetual weaving and unweaving of ourselves.

[0] http://www.mccoyspace.com/nyu/10_s/ideas/texts/week02-texts....