As the Tufte code samples indicate, plotting using base R graphics can be headache inducing, though, which is why the inclusion of a ggplot2 implementation is helpful. The other themes included with ggthemes seem pretty interesting as well.
An important thing to note about plotting with R is that if you can, you should use R in OS X for antialiasing. It makes a very notable difference for high-res charts (see my post), and it's clear that there's a lot of pixelation around the text and lines in the OP. Here's the Tuft line ggplot2 plot rendered on my MacBook: http://i.imgur.com/DC6TgW9.png