This is very helpful, thank you. In particular thanks for the tip about not lining things up in rows, because that's just what I would have done. I could probably write a script so that I could design things in neat rows on a screen, and then it could fit it for me in a tight bunch, and then I could wrap it.
Are there smart ways to use decoupling capacitors to get more?
How do you get a feel for how much room you have to play with as far as MHz? Is it just a case that you start with something small, and then go up until it breaks?
Are there practicalities of what chip generations is possible with wire-wrap? 6502 would be possible with wire-wrap. What about Motorolla 68k? (Also - what is the most sophisticated 68k chip that's still commercially available? Speed and memory addressing are important, MMU is not.)