A deep exploration of the CPython code-base with Philip Guo
talkpython.fm
talkpython.fm
One of the ideas discussed in it is the importance of knowing your platform. He had an idea for a tool which many other people had before, but it was the deep knowledge of python interpreter that allowed him to create the tool that was actually usable (IncPy).
And the videos from "CPython internals: A ten-hour codewalk through the Python interpreter source code" are here: