So I checked my rs1421085 status and luckily I don't have the obesity variant.
I guess the cause of my overweight is my laziness then :)
I guess the cause of my overweight is my laziness then :)
"In risk individuals, a thymine (T) is replaced by a cytosine (C) nucleobase, which disrupts repression of the control region and turns on IRX3 and IRX5. This then turns off thermogenesis, leading to lipid accumulation and ultimately obesity... Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes."
So yes, CC is taken to mean "risk" and CT is likewise "non-risk".
As always, one finding doesn't indicate ultimate truth, so take this all with a grain of salt (or not, depending on what 23andMe has to say about your sodium intake).
"Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes."
Hurry up CRISPR-CAS9. Need this fixed!
It might show you some genetic disorders. As it did for me which I then had confirmed by a doctor. Now I supplement a special form of Folic acid and my homocysteine blood levels are normal (they have been elevated for the last 30 years I guess, wich is not too good).
Not sure if I should be glad I'm not at risk or sad that I don't have that excuse.